Investigating The Single Nucleotide Polymorphism A1166C in Angiotensin II Type 1 Receptor Gene and Its Association with Hypertension in Patients in Syria

ABSTRACT: There are reported associations between a polymorphism of the angiotensin II type 1 receptor (AGTR.1/A1166C) gene and hypertension in some populations. To determine if the single nucleotide polymorphism (SNP) A1166C in AGTR.1 is associated with hypertension in Aleppo, we recruited twenty-eight patients with hypertension and thirty-five healthy subjects as the control group. The AGTR.1 polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) based method. Results: The genotypic frequency of AA was 88.9%, that for AC was 11.1% and no CC type was detected. There was no significant difference in genotype and allele frequencies between hypertensive and nonhypertensive patients (p>0.05). Our results indicated that AGTR.1 A/C1166 polymorphism was not associated with hypertension in Syrian population.